Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 18/20 | 0.53 |
| ▸ | CX3CR1 | P49238 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCR7 | P32248 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6352542 | 1.00 | CXCR2 (0.53) | CXCR2CX3CR1MAPK1CCR7 | |
| SCHEMBL6354297 | 0.89 | CXCR2 (0.64) | CXCR2CX3CR1CCR7 | |
| SCHEMBL6355072 | 0.89 | CXCR2 (0.66) | CXCR2CX3CR1CCR7 | |
| SCHEMBL6354650 | 0.88 | CXCR2 (0.54) | CXCR2CX3CR1CCR7 | |
| SCHEMBL6357058 | 0.88 | CXCR2 (0.52) | CXCR2CX3CR1CCR7 | |
| SCHEMBL3852955 | 0.84 | CXCR2 (0.68) | CXCR2CX3CR1MAPK1CCR7 | |
| SCHEMBL6353141 | 0.82 | CXCR2 (0.55) | CXCR2CX3CR1CCR7 | |
| SCHEMBL6354597 | 0.81 | CXCR2 (0.45) | CXCR2CX3CR1CCR7 | |
| SCHEMBL6360635 | 0.80 | CXCR2 (0.75) | CXCR2CCR7 | |
| SCHEMBL6353801 | 0.79 | CXCR2 (0.65) | CXCR2CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265899-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001058902-A1 | PYRIMIDINE COMPOUNDS AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | WO | disclosed |