SCHEMBL7604495

SCHEMBL7604495

CN(C)C[C@H]1COc2ccccc2C1=O

nearest known ligand 0.61

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.61
METAP1 P53582 2/20 0.56
THRA P10827 1/20 0.55
THRB P10828 1/20 0.55
SIGMAR1 Q99720 2/20 0.51
CYP19A1 P11511 9/20 0.50
HTR1A P08908 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31073649 1.00 MAOB (0.61) MAOBMETAP1THRATHRBSIGMAR1
SCHEMBL6775349 1.00 MAOB (0.61) MAOBMETAP1THRATHRBSIGMAR1
Hydrochloric Acid SCHEMBL8607859 0.98 MAOB (0.60) MAOBMETAP1THRATHRBSIGMAR1
SCHEMBL6142756 0.85 METAP1 (0.54) MAOBMETAP1THRATHRBSIGMAR1
SCHEMBL28243797 0.79 MAOB (0.63) MAOBSIGMAR1CYP19A1HTR1A
SCHEMBL12164223 0.79 MAOB (0.67) MAOBSIGMAR1CYP19A1HTR1A
SCHEMBL27890288 0.79 MAOB (0.67) MAOBSIGMAR1CYP19A1HTR1A
SCHEMBL7300027 0.78 MAOB (0.51) MAOBMETAP1THRATHRBSIGMAR1
SCHEMBL7303097 0.77 MAOB (0.50) MAOBMETAP1SIGMAR1CYP19A1HTR1A
SCHEMBL13378964 0.77 MAOB (0.60) MAOBSIGMAR1CYP19A1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0922703-B1 Substituted heterocyclic benzocycloalkenes and their use as analgesically active compounds GRUENENTHAL GMBH (DE) 2002-12-04 EP disclosed
US-6013809-A ANALGESICS GRUENENTHAL GMBH (DE) 2000-01-11 US disclosed
EP-0922703-A1 Substituted heterocyclic benzocycloalkenes and their use as analgesically active compounds Grünenthal GmbH (DE) 1999-06-16 EP disclosed