Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 7/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.41 |
| ▸ | RELA | Q04206 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7604669 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7605083 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7614301 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7606165 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7610580 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7609545 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7614162 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7612233 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| SCHEMBL7605129 | 1.00 | KDM4E (0.47) | KDM4EKDM4AKDM4CFAAHLMNA | |
| Hydrochloric Acid SCHEMBL14735633 | 0.99 | KDM4E (0.46) | KDM4EKDM4AKDM4CFAAHLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846685-B1 | 3-Hydroxypyridine-2-carboxylic acid amide esters, their preparation and their use as medicaments | HOECHST AG (DE) | 2002-03-13 | — | — | EP | disclosed |
| EP-0846685-A1 | 3-Hydroxypyridine-2-carboxylic acid amide esters, their preparation and their use as medicaments | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-10 | — | — | EP | disclosed |