⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6649387 | 0.71 | — | — | |
| SCHEMBL12848613 | 0.69 | — | — | |
| SCHEMBL7975737 | 0.63 | — | — | |
| SCHEMBL9483612 | 0.62 | — | — | |
| SCHEMBL18754881 | 0.62 | — | — | |
| SCHEMBL3104317 | 0.58 | TSHR (0.31) | — | |
| SCHEMBL4908627 | 0.56 | — | — | |
| SCHEMBL11866635 | 0.56 | — | — | |
| SCHEMBL24105 | 0.56 | — | — | |
| SCHEMBL12764199 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776464-A | The preparation method of furan tebufenozide, intermediate and preparation method thereof | 江苏省农药研究所股份有限公司 | 2019-05-21 | — | — | CN | claimed |
| CN-119836420-A | 2-Indolone compounds as VEGFR and PKa dual-target inhibitors, preparation method and application thereof | 远森制药（杭州）有限公司 | 2025-04-15 | — | — | CN | disclosed |
| CN-109776464-A | The preparation method of furan tebufenozide, intermediate and preparation method thereof | 江苏省农药研究所股份有限公司 | 2019-05-21 | — | — | CN | disclosed |
| US-8399473-B2 | Macrocyclic spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease | Merck, Sharp & Dohme, Corp. (US) | 2013-03-19 | — | — | US | disclosed |
| EP-2073635-B1 | MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |
| US-20100029701-A1 | MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LLC | 2010-02-04 | — | — | US | disclosed |