Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 9/20 | 0.67 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615020 | 0.87 | PDE7A (0.55) | PDE7ALMNAKMT2ATDP1PDE7B | |
| SCHEMBL7607910 | 0.81 | PDE7A (0.78) | PDE7ALMNAKMT2ATDP1PDE7B | |
| SCHEMBL23407733 | 0.80 | PDE7A (0.68) | PDE7AKMT2APDE7BPDE4BPDE4D | |
| SCHEMBL8308859 | 0.80 | PDE7A (1.00) | PDE7ALMNAKMT2ATDP1PDE7B | |
| SCHEMBL9629212 | 0.80 | PDE7A (0.56) | PDE7ALMNAKMT2ATDP1PDE7B | |
| SCHEMBL2418894 | 0.79 | SMN1; SMN2 (0.52) | PDE7ALMNAKMT2ATDP1MAPT | |
| SCHEMBL10924733 | 0.79 | PDE7A (0.63) | PDE7ALMNAKMT2ATDP1PDE7B | |
| SCHEMBL20379380 | 0.79 | MAPT (0.52) | PDE7ALMNAKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL29881314 | 0.79 | PDE7A (0.61) | PDE7ALMNAKMT2APDE7BMAPT | |
| SCHEMBL20379425 | 0.79 | PDE7A (0.61) | PDE7ALMNAKMT2APDE7BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2002541141-A | — | — | 2002-12-03 | — | — | JP | claimed |
| EP-1165504-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000059878-A2 | INHIBITORS OF LFA-1 BINDING TO ICAMs AND USES THEREOF | ICOS CORPORATION (US) | 2000-10-12 | — | — | WO | claimed |