Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 19/20 | 0.84 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.84 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.84 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.84 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.84 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.77 |
| ▸ | ADRB2 | P07550 | 5/20 | 0.74 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606564 | 1.00 | CASR (0.84) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7603995 | 0.95 | CASR (0.77) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7603992 | 0.95 | CASR (0.77) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6377132 | 0.91 | CASR (1.00) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6377127 | 0.91 | CASR (1.00) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL6376960 | 0.91 | CASR (0.98) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL7610274 | 0.90 | CASR (0.85) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3348716 | 0.90 | CASR (0.91) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3348714 | 0.90 | CASR (0.91) | CASRSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3348707 | 0.90 | CASR (0.91) | CASRSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | claimed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | claimed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | disclosed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | disclosed |