Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.69 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.51 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PRKCA | P17252 | 2/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.47 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4912094 | 0.89 | MAPK14 (0.55) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4593692 | 0.89 | MAPK14 (0.55) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4617697 | 0.89 | MAPK14 (0.68) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL7611152 | 0.88 | MAPK14 (0.69) | MAPK14CSNK1DMAPK13MAPK12MAPK11 | |
| SCHEMBL4593493 | 0.88 | MAPK14 (0.61) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4593419 | 0.85 | MAPK14 (0.56) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4593943 | 0.85 | MAPK14 (0.54) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4593958 | 0.84 | MAPK14 (0.55) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL27471215 | 0.84 | MAPK14 (0.52) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 | |
| SCHEMBL4593390 | 0.83 | MAPK14 (0.54) | MAPK14CSNK1DCSNK1EMAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1264827-A1 | Process for the preparation of Tosylbenzylformamides | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-11 | — | — | EP | disclosed |
| EP-0809499-A4 | CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE | SMITHKLINE BEECHAM CORP (US) | 1998-10-14 | — | — | EP | disclosed |
| EP-0809499-A1 | CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996021452-A1 | CERTAIN 1,4,5-TRI-SUBSTITUTED IMIDAZOLE COMPOUNDS USEFUL AS CYTOKINE | SMITHKLINE BEECHAM CORPORATION (US) | 1996-07-18 | — | — | WO | disclosed |