Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.52 |
| ▸ | SYK | P43405 | 5/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.52 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177896 | 0.93 | IRAK4 (0.61) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL21187255 | 0.93 | IRAK4 (0.61) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL1709800 | 0.81 | IRAK4 (0.49) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL3712626 | 0.76 | IRAK4 (0.44) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL20261989 | 0.76 | IRAK4 (0.55) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL20261991 | 0.76 | IRAK4 (0.55) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL16595153 | 0.76 | IRAK4 (0.44) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL20273951 | 0.75 | KMT2A (0.47) | IRAK4SYKDAPK3JAK2STK16 | |
| SCHEMBL27393844 | 0.74 | CYP1A2 (0.65) | CYP1A2CLK4CYP3A4CYP2C19TSHR | |
| SCHEMBL1709924 | 0.73 | MERTK (0.68) | IRAK4SYKDAPK3JAK2STK16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122846-A1 | FURO[3,2-d]PYRIMIDINE COMPOUNDS | CDK2, DPYD, CDK3 | IRAK4 453/4885SYK 1176/4885DAPK3 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.