SCHEMBL7607530

SCHEMBL7607530

COc1cc2c(cc1Br)CC(=O)NN=C2c1ccccc1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.67
CYP3A4 P08684 1/20 0.67
CYP2C9 P11712 1/20 0.67
MAPK1 P28482 1/20 0.67
CYP2C19 P33261 1/20 0.67
GRIA2 P42262 3/20 0.46
AXL P30530 1/20 0.42
PDGFRB P09619 1/20 0.42
MAPK10 P53779 1/20 0.40
ROCK2 O75116 1/20 0.39
NAMPT P43490 1/20 0.39
SLC2A1 P11166 1/20 0.39
TDP2 O95551 1/20 0.38
PDE4A P27815 1/20 0.38
PDE4B Q07343 1/20 0.38
PDE4C Q08493 1/20 0.38
PDE4D Q08499 1/20 0.38
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
HTR2A P28223 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5488342 0.92 CYP1A2 (0.77) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407689 0.91 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7409537 0.86 CYP1A2 (0.69) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7409542 0.84 CYP1A2 (0.65) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7228098 0.84 CYP1A2 (0.62) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407379 0.84 CYP1A2 (0.80) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7227570 0.84 CYP1A2 (0.58) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7411882 0.83 CYP1A2 (0.67) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL8452460 0.81 CYP1A2 (0.56) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19
SCHEMBL7407596 0.80 CYP1A2 (0.78) CYP1A2CYP3A4CYP2C9MAPK1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888313-B1 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS SCHERING AG (DE) 2002-04-17 EP disclosed
US-6200970-B1 FOR TREATING A DISEASE ASSOCIATED WITH OVERSTIMULATION OF AN AMPA RECEPTOR, OR HYPERACTIVITY OF AN EXCITATORY AMINO ACID SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-13 US disclosed
EP-0888313-A1 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1999-01-07 EP disclosed
WO-1997028135-A1 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1997-08-07 WO disclosed