Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.75 |
| ▸ | BACE2 | Q9Y5Z0 | 14/20 | 0.75 |
| ▸ | CTSD | P07339 | 5/20 | 0.65 |
| ▸ | CTSE | P14091 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889542 | 1.00 | BACE1 (0.75) | BACE1BACE2CTSDCTSE | |
| SCHEMBL4882318 | 0.94 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL7612190 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSDCTSE | |
| SCHEMBL4887015 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSDCTSE | |
| SCHEMBL5354131 | 0.89 | BACE1 (0.81) | BACE1BACE2CTSDCTSE | |
| SCHEMBL3347634 | 0.89 | BACE1 (0.81) | BACE1BACE2CTSDCTSE | |
| SCHEMBL5833797 | 0.89 | BACE1 (0.73) | BACE1BACE2CTSDCTSE | |
| SCHEMBL4887067 | 0.89 | BACE1 (0.68) | BACE1BACE2CTSDCTSE | |
| SCHEMBL7603961 | 0.89 | BACE1 (0.83) | BACE1BACE2CTSD | |
| SCHEMBL4889675 | 0.89 | BACE1 (0.83) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265849-A2 | COMPOUNDS AND METHODS TO TREAT ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001070672-A2 | COMPOUNDS AND METHODS TO TREAT ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2001-09-27 | — | — | WO | claimed |