Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.83 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.83 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29651353 | 0.91 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL1056361 | 0.91 | CYP1A2 (1.00) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7607849 | 0.86 | CYP1A2 (0.61) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7405387 | 0.83 | CYP1A2 (0.78) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7605981 | 0.82 | CYP1A2 (0.76) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7407689 | 0.80 | CYP1A2 (0.80) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7407379 | 0.80 | CYP1A2 (0.80) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7407596 | 0.79 | CYP1A2 (0.78) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL5488342 | 0.78 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 | |
| SCHEMBL7615727 | 0.78 | CYP1A2 (0.58) | CYP1A2CYP3A4CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888313-B1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AG (DE) | 2002-04-17 | — | — | EP | disclosed |
| US-6200970-B1 | FOR TREATING A DISEASE ASSOCIATED WITH OVERSTIMULATION OF AN AMPA RECEPTOR, OR HYPERACTIVITY OF AN EXCITATORY AMINO ACID | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-03-13 | — | — | US | disclosed |
| EP-0888313-A1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997028135-A1 | 2,3-BENZODIAZEPINE DERIVATIVES AND THEIR USE AS AMPA-RECEPTOR INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-08-07 | — | — | WO | disclosed |