SCHEMBL7607994

SCHEMBL7607994

CCC(=O)Oc1c(O)c(C(=O)c2ccccc2)cc(C(=O)c2ccccc2)c1O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ELANE P08246 2/20 0.56
BCL2 P10415 3/20 0.47
MCL1 Q07820 3/20 0.47
MAPT P10636 5/20 0.45
KMT2A Q03164 3/20 0.45
HTT P42858 2/20 0.45
MEN1 O00255 2/20 0.45
MAPK1 P28482 3/20 0.44
KDM4E B2RXH2 2/20 0.44
HSD17B10 Q99714 2/20 0.44
ALOX15 P16050 1/20 0.44
HPGD P15428 3/20 0.44
LMNA P02545 2/20 0.43
ALDH1A1 P00352 1/20 0.43
CYP1A2 P05177 1/20 0.43
PGR P06401 1/20 0.43
CYP2D6 P10635 1/20 0.43
SLC6A2 P23975 1/20 0.43
PDE4A P27815 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3348503 0.81 ELANE (0.55) ELANEMAPTKMT2AHTTMEN1
SCHEMBL27485334 0.78 ELANE (0.55) ELANEBCL2MCL1MAPTKMT2A
SCHEMBL20458688 0.77 HPGD (0.67) ELANEMAPTKMT2AHTTMEN1
SCHEMBL1683548 0.76 ELANE (0.62) ELANEMAPTKMT2AMEN1MAPK1
SCHEMBL11442392 0.76 MAPT (0.46) ELANEMAPTKMT2AHTTMEN1
SCHEMBL13133219 0.74 ELANE (0.51) ELANEMAPTKMT2AHTTMEN1
SCHEMBL15313729 0.74 BCL2 (0.68) BCL2MCL1MAPTKMT2AHTT
SCHEMBL5486182 0.74 ELANE (0.54) ELANEMAPTKMT2AHTTMAPK1
SCHEMBL5672203 0.73 BCL2 (0.53) BCL2MCL1MAPTKMT2AHTT
SCHEMBL3140205 0.73 BCL2 (0.57) BCL2MCL1MAPTKMT2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6395922-B1 REACTION OF 4,6-DIBENZOYLRESORCINOL AND PARA-ALDEHYDE WITH SECONDARY AMINE GENERAL ELECTRIC COMPANY 2002-05-28 US disclosed
EP-0854127-B1 Novel compounds based on dibenzoylresorcinol and related compositions and articles GEN ELECTRIC (US) 2002-04-17 EP disclosed
US-6143918-A REACTING A MIXTURE OF A 4,6-DIBENZOYLRESORCINOL AND A PARA-ALDEHYDE WITH A SECONDARY AMINE CATALYST AND A CARBOXYLIC ACID SOLVENT AND REACTING THE METHYLENE CARBOXYLATE COMPOUND FORMED IN STEP WITH AN ALCOHOL OR A CARBOXYLIC ACID GENERAL ELECTRIC COMPANY (US) 2000-11-07 US disclosed
US-5981073-A ULTRAVIOLET LIGHT ABSORBERS GENERAL ELECTRIC COMPANY (US) 1999-11-09 US disclosed
EP-0854127-A1 Novel compounds based on dibenzoylresorcinol and related compositions and articles GENERAL ELECTRIC COMPANY (US) 1998-07-22 EP disclosed