Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 18/20 | 0.75 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.60 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7608752 | 0.99 | CASR (0.73) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL7606721 | 0.93 | CASR (0.78) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL14382960 | 0.91 | CASR (0.90) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL5509997 | 0.89 | CASR (0.88) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL5508953 | 0.87 | CASR (0.77) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL14382945 | 0.86 | CASR (1.00) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL14382943 | 0.86 | CASR (1.00) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL14382947 | 0.86 | CASR (1.00) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| SCHEMBL14383005 | 0.85 | CASR (0.80) | CASRADRB2ADRB3CYP2D6SLC6A2 | |
| Hydrochloric Acid SCHEMBL5510007 | 0.85 | CASR (0.80) | CASRADRB2ADRB3CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | claimed |
| EP-1070048-A4 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2001-11-07 | — | — | EP | claimed |
| EP-1070048-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999051569-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-10-14 | — | — | WO | claimed |
| US-6395919-B1 | Calcilytic compounds | SMITHKLINE BEECHAM CORPORATION | 2002-05-28 | — | — | US | disclosed |