Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.81 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.81 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.81 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.81 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4915662 | 0.90 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL4587383 | 0.85 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL30023277 | 0.84 | MAPK14 (0.87) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| Bromide SCHEMBL30021492 | 0.83 | MAPK14 (0.85) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL4912059 | 0.80 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL13038792 | 0.78 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL4915990 | 0.75 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL1387655 | 0.72 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11MAP4K4 | |
| SCHEMBL4906653 | 0.72 | MAPK14 (0.63) | MAPK14MAPK13MAPK12MAPK11KDM4C | |
| SCHEMBL6583564 | 0.71 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1229035-A1 | Imine intermediates for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-07 | — | — | EP | disclosed |