Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 11/20 | 0.50 |
| ▸ | PDE5A | O76074 | 4/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129771 | 0.95 | MAPT (0.57) | MAPTNPSR1GBA1PDE5AMEN1 | |
| SCHEMBL5124037 | 0.91 | MAPT (0.61) | MAPTNPSR1GBA1PDE5AMEN1 | |
| SCHEMBL7614371 | 0.90 | PRKCI (0.51) | MAPTNPSR1GBA1PDE5ACYP11B1 | |
| SCHEMBL7611781 | 0.90 | MAPT (0.51) | MAPTNPSR1GBA1PDE5ACYP11B1 | |
| SCHEMBL7610379 | 0.89 | PRKCI (0.50) | KDM4E | |
| SCHEMBL7617081 | 0.87 | MAPT (0.49) | MAPTNPSR1GBA1PDE5ACYP11B1 | |
| SCHEMBL7507644 | 0.86 | MAPT (0.56) | MAPTNPSR1GBA1PDE5AMEN1 | |
| SCHEMBL7620678 | 0.86 | NPC1 (0.40) | MAPTNPSR1GBA1PDE5AKMT2A | |
| SCHEMBL7622025 | 0.86 | MAPT (0.47) | MAPTNPSR1GBA1PDE5ACYP11B1 | |
| SCHEMBL5123309 | 0.86 | MAPT (0.69) | MAPTNPSR1GBA1PDE5AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6133271-A | Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives | CELL PATHWAYS, INC. (US) | 2000-10-17 | — | — | US | disclosed |