Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15039606 | 0.97 | — | — | |
| Bromide SCHEMBL11799054 | 0.78 | — | — | |
| SCHEMBL13479936 | 0.74 | — | — | |
| SCHEMBL19806013 | 0.72 | — | — | |
| SCHEMBL21395060 | 0.72 | — | — | |
| SCHEMBL11060831 | 0.72 | — | — | |
| SCHEMBL18077387 | 0.72 | — | — | |
| SCHEMBL21394892 | 0.72 | — | — | |
| SCHEMBL14508108 | 0.72 | — | — | |
| Bromide SCHEMBL8719198 | 0.72 | BLM (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888293-B1 | N-ACYLAMINOALKYLHYDRAZINECARBOXIMIDAMIDES | ALTEON INC (US) | 2002-03-27 | — | — | EP | disclosed |
| US-5877217-A | INHIBITING THE FORMATION OF ADVANCED GLYCOSYLATION ENDPRODUCTS OF TARGET PROTEINS. INHIBITING THE DISCOLORATION OF TEETH. | ALTEON INC. (US) | 1999-03-02 | — | — | US | disclosed |
| EP-0888293-A1 | N-ACYLAMINOALKYLHYDRAZINECARBOXIMIDAMIDES | ALTEON, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997023447-A1 | N-ACYLAMINOALKYLHYDRAZINECARBOXIMIDAMIDES | ALTEON INC. (US) | 1997-07-03 | — | — | WO | disclosed |
| US-5612332-A | INHIBITING PROTEIN GLYCOSYLATION | ALTEON INC. (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996040663-A1 | DI- AND TRI-AMINOGUANIDINES AND THEIR USE TO INHIBIT THE ADVANCED GLYCOSYLATION OF PROTEINS | ALTEON INC. (US) | 1996-12-19 | — | — | WO | disclosed |