Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607804 | 1.00 | CA12 (0.55) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL7610183 | 1.00 | CA12 (0.55) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL5827040 | 0.92 | CA12 (0.57) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL8099178 | 0.92 | POLB (0.50) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL965009 | 0.84 | CA12 (0.54) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL8788725 | 0.84 | CA12 (0.57) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL8563716 | 0.84 | CA12 (0.54) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL1010088 | 0.83 | NOTUM (0.56) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL1010118 | 0.83 | CA12 (0.51) | CA12CA1CA2CA9NOTUM | |
| SCHEMBL15347006 | 0.83 | HDAC1 (0.53) | CA12CA2CA9NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863872-B1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | SYNGENTA LTD (GB) | 2002-05-29 | — | — | EP | disclosed |
| EP-0863872-A1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1998-09-16 | — | — | EP | disclosed |
| US-5710283-A | Preparation of chiral pyrrolidinone derivatives | ZENECA LIMITED (GB) | 1998-01-20 | — | — | US | disclosed |
| WO-1997019920-A1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-05 | — | — | WO | disclosed |