Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 13/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7605538 | 1.00 | MCHR1 (0.54) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL7607513 | 0.88 | MCHR1 (0.53) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL8788455 | 0.87 | MCHR1 (0.52) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL7613749 | 0.85 | MCHR1 (0.50) | MCHR1NOTUM | |
| SCHEMBL8685457 | 0.82 | MCHR1 (0.50) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL7610270 | 0.81 | MCHR1 (0.52) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL7609602 | 0.81 | MCHR1 (0.52) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL8551967 | 0.81 | MCHR1 (0.52) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL9273396 | 0.80 | NOTUM (0.59) | MCHR1NOTUMROCK2ROCK1DRD2 | |
| SCHEMBL7608385 | 0.79 | NOTUM (0.52) | MCHR1NOTUMROCK2ROCK1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863872-B1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | SYNGENTA LTD (GB) | 2002-05-29 | — | — | EP | disclosed |