Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 15/20 | 0.68 |
| ▸ | RHOC | P08134 | 2/20 | 0.55 |
| ▸ | RHOA | P61586 | 2/20 | 0.55 |
| ▸ | TACR3 | P29371 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7611711 | 1.00 | TACR1 (0.68) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7618575 | 0.93 | TACR1 (0.66) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7615335 | 0.93 | TACR1 (0.66) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7612746 | 0.91 | TACR1 (0.64) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7612741 | 0.91 | TACR1 (0.64) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7616504 | 0.91 | TACR1 (0.69) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7616496 | 0.91 | TACR1 (0.69) | TACR1RHOCRHOATACR3CCR2 | |
| SCHEMBL7611998 | 0.91 | TACR1 (0.82) | TACR1RHOCRHOATACR3 | |
| SCHEMBL7612006 | 0.91 | TACR1 (0.82) | TACR1RHOCRHOATACR3 | |
| SCHEMBL7614357 | 0.90 | TACR1 (0.71) | TACR1RHOCRHOATACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783490-B1 | 1-ACYL-4-ALIPHATIC AMINOPIPERIDINE COMPOUNDS | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | claimed |
| US-5935951-A | ANTAGONIST AGAINST SUBSTANCE P | NOVARTIS FINANCE CORPORATION (US) | 1999-08-10 | — | — | US | claimed |
| EP-0783490-A1 | 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE COMPOUNDS | Novartis AG (CH) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010562-A1 | 1-ACYL-4-ALIPHATYLAMINOPIPERIDINE COMPOUNDS | NOVARTIS AG (CH) | 1996-04-11 | — | — | WO | claimed |
| EP-0783490-B1 | 1-ACYL-4-ALIPHATIC AMINOPIPERIDINE COMPOUNDS | NOVARTIS AG (CH) | 2002-02-06 | — | — | EP | disclosed |