Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 14/20 | 0.63 |
| ▸ | CCNC | P24863 | 13/20 | 0.63 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.56 |
| ▸ | SELE | P16581 | 6/20 | 0.56 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CLK2 | P49760 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052520 | 0.91 | CDK8 (0.64) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7054418 | 0.89 | CDK8 (0.65) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7051655 | 0.87 | CDK8 (0.56) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7058200 | 0.85 | CDK8 (0.57) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7055183 | 0.84 | CDK8 (0.65) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7058187 | 0.79 | CDK8 (0.54) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7051842 | 0.78 | CDK8 (1.00) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7054492 | 0.74 | CDK8 (0.66) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7053179 | 0.74 | MAP3K8 (0.63) | CDK8CCNCICAM1SELEVCAM1 | |
| SCHEMBL7059696 | 0.74 | PIM1 (0.62) | CDK8CCNCICAM1SELEVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181296-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | disclosed |
| EP-1090009-A2 | CELL ADHESION-INHIBITING ANTINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000075145-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-12-14 | — | — | WO | disclosed |
| WO-1999062908-A2 | CELL ADHESION-INHIBITING ANTINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-12-09 | — | — | WO | disclosed |