Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 14/20 | 0.54 |
| ▸ | CXCR1 | P25024 | 13/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7614978 | 1.00 | CXCR2 (0.54) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817506 | 0.82 | CXCR2 (0.70) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817502 | 0.82 | CXCR2 (0.70) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL7614982 | 0.81 | CXCR2 (0.46) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817254 | 0.77 | CXCR2 (0.49) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6817256 | 0.77 | CXCR2 (0.49) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6917268 | 0.77 | CXCR2 (0.48) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6917264 | 0.77 | CXCR2 (0.48) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL7553940 | 0.75 | CXCR2 (0.74) | CXCR2CXCR1ADRB3TSPOSLC6A3 | |
| SCHEMBL6550053 | 0.70 | CXCR2 (1.00) | CXCR2CXCR1ADRB3TSPOSLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1152675-C | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-06-09 | — | — | CN | claimed |
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | claimed |
| CN-1152675-C | IL-8 receptor antagonists | ʷ��˿�������ȳ�ķ����˾ | 2004-06-09 | — | — | CN | disclosed |
| EP-0929302-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-31 | — | — | EP | disclosed |
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | disclosed |
| CN-1232398-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1999-10-20 | — | — | CN | disclosed |
| EP-0929302-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |