Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2J2 | P51589 | 13/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.71 |
| ▸ | HRH1 | P35367 | 2/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terfenadone SCHEMBL11364486 | 0.90 | CYP2J2 (1.00) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11826925 | 0.90 | CYP2J2 (1.00) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Terfenadone SCHEMBL11801242 | 0.89 | CYP2J2 (0.98) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL11830435 | 0.89 | CYP2J2 (0.98) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL1395734 | 0.88 | CYP2J2 (0.84) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL2763954 | 0.88 | CYP2J2 (0.84) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL11798280 | 0.88 | CYP2J2 (0.84) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL18765452 | 0.88 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| SCHEMBL3737586 | 0.88 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 | |
| Hydrochloric Acid SCHEMBL3681404 | 0.88 | CYP2J2 (0.82) | CYP2J2CYP3A4CYP2C9CYP2B6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635004-B1 | 4-DIPHENYLMETHYL PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERRELL PHARMA INC (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5663353-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5654433-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-08-05 | — | — | US | disclosed |
| US-5652370-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-29 | — | — | US | disclosed |
| US-5650516-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5644061-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-01 | — | — | US | disclosed |
| US-5631375-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS, INC. (US) | 1997-05-20 | — | — | US | disclosed |
| US-5618940-A | Process for piperidine derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0635004-A1 | 4-DIPHENYLMETHYL PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERRELL PHARMACEUTICALS INC. (US) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993021156-A1 | 4-DIPHENYLMETHYL PIPERIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-10-28 | — | — | WO | disclosed |