⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1236225 | 1.00 | — | — | |
| SCHEMBL17316208 | 0.82 | — | — | |
| SCHEMBL16600345 | 0.82 | — | — | |
| SCHEMBL5987889 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL128419 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL3425314 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL1044688 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL6409783 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL130943 | 0.78 | AKR1B1 (0.43) | — | |
| SCHEMBL16600257 | 0.76 | AKR1B1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2916837-A1 | PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014074421-A1 | PRODRUG BIPYRIDYLAMINOPYRIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-05-15 | — | — | WO | disclosed |
| CN-101443014-A | Compound (I) | ASTRAZENECA AB (SE) | 2009-05-27 | — | — | CN | disclosed |
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |