Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 8/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.40 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.39 |
| ▸ | PNP | P00491 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442906 | 0.89 | ADORA2A (0.41) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL7173171 | 0.87 | ADORA2A (0.40) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL27842808 | 0.84 | PDE4A (0.53) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5664376 | 0.82 | PDE4A (0.39) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL28071828 | 0.81 | PNP (0.45) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL11215534 | 0.81 | PNP (0.53) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL7617790 | 0.80 | PNP (0.36) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL3512359 | 0.80 | PDE4A (0.37) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL8423728 | 0.79 | PDE4A (0.38) | ADORA2AADORA2BPDE2APDE1APDE1B | |
| SCHEMBL3671339 | 0.79 | DPP4 (0.44) | ADORA2AADORA2BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165570-A2 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | Metabasis Therapeutics, Inc. (US) | 2002-01-02 | — | — | EP | claimed |
| WO-2000052015-A2 | NOVEL PHOSPHORUS-CONTAINING PRODRUGS | METABASIS THERAPEUTICS, INC. (US) | 2000-09-08 | — | — | WO | claimed |
| EP-0679390-A2 | Sprayable topical pharmaceutical compositions | Zyma SA (CH) | 1995-11-02 | — | — | EP | disclosed |