SCHEMBL7617840

SCHEMBL7617840

COC(=O)C(=Cc1ccc(OC)cc1)CC(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3B P49841 1/20 0.50
RECQL P46063 1/20 0.50
PTGS2 P35354 1/20 0.49
GLO1 Q04760 3/20 0.48
MAPT P10636 3/20 0.48
RAB9A P51151 2/20 0.48
THRB P10828 2/20 0.48
KDM4E B2RXH2 2/20 0.48
NPC1 O15118 1/20 0.48
ATM Q13315 1/20 0.47
CYP1A2 P05177 1/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
LMNA P02545 1/20 0.46
POLB P06746 1/20 0.45
KMT2A Q03164 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7934147 1.00 GSK3B (0.50) GSK3BRECQLPTGS2GLO1MAPT
SCHEMBL6654010 0.89 GSK3B (0.51) GSK3BRECQLGLO1MAPTRAB9A
SCHEMBL6654014 0.89 GSK3B (0.51) GSK3BRECQLGLO1MAPTRAB9A
SCHEMBL31483404 0.87 GSK3B (0.50) GSK3BPTGS2MAPTTHRBKDM4E
SCHEMBL7132118 0.85 RECQL (0.51) RECQLGLO1MAPTRAB9AKDM4E
SCHEMBL1915838 0.85 RECQL (0.69) RECQLMAPTTHRBKMT2A
SCHEMBL1915837 0.85 RECQL (0.69) RECQLMAPTTHRBKMT2A
SCHEMBL1915834 0.85 RECQL (0.69) RECQLMAPTTHRBKMT2A
SCHEMBL27725356 0.84 RECQL (0.58) RECQLPTGS2LMNAPOLBKMT2A
SCHEMBL2171291 0.84 MEN1 (0.50) RECQLMAPTCYP1A2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1265885-A2 HYDROXYLATED/CARBOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2002-12-18 EP disclosed
WO-2001070719-A2 HYDROXYLATED/CARBOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL, INC. (US) 2001-09-27 WO disclosed
US-6242600-B1 ANTIISCHEMIC AGENTS, ANTICOAGULANTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2001-06-05 US disclosed
CN-1031340-C Process for preparing substituted 2H-benzotriazole liquid mixtures CIBA GEIGY AG (CH) 1996-03-20 CN disclosed
EP-0337942-B1 Liquid substituted 2H-benzotriazole mixtures CIBA GEIGY AG (CH) 1994-07-06 EP disclosed
US-5240975-A Photostability CIBA-GEIGY CORPORATION (US) 1993-08-31 US disclosed
EP-0189374-B1 LIQUID MIXTURES OF 2-(HYDROXY-3-BRANCHED ALKYL-5-METHYLPHENYL)-2H-BENZOTRIAZOLE, PROCESS FOR THEIR PREPARATION AND STABILIZED COMPOSITIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1992-03-18 EP disclosed
US-5095062-A Photostability CIBA-GEIGY CORPORATION (US) 1992-03-10 US disclosed
US-4973701-A LIGHT STABILIZERS FOR PHOTOGRAPHY AND POLYMERS CIBA-GEIGY CORPORATION (US) 1990-11-27 US disclosed
CN-1037337-A Substituted 2H-benzotriazole liquid mixtures CIBA GEIGY AG (CH) 1989-11-22 CN disclosed
EP-0337942-A1 Liquid substituted 2H-benzotriazole mixtures CIBA-GEIGY AG (CH) 1989-10-18 EP disclosed
US-4675352-A PHOTOSTABILITY CIBA-GEIGY CORPORATION (US) 1987-06-23 US disclosed
US-4587346-A ALKYLATION WITH ALKENE AND ACID CATALYST CIBA-GEIGY CORPORATION (US) 1986-05-06 US disclosed
US-4524165-A 1,4-CYCLOHEXANEDICARBOXYLIC ACID AND 1,4-CYCLOHEXANE DIOL MONOMERS; POLYALKYLENE GLCOLS; STABILIZER MIXTURE EASTMAN KODAK COMPANY (US) 1985-06-18 US disclosed