Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 15/20 | 0.61 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618024 | 1.00 | NAMPT (0.61) | NAMPTSLC2A1IMPDH2MEN1KMT2A | |
| SCHEMBL7619205 | 0.96 | SLC2A1 (0.66) | NAMPTSLC2A1IMPDH2MEN1KMT2A | |
| SCHEMBL7619200 | 0.96 | SLC2A1 (0.66) | NAMPTSLC2A1IMPDH2MEN1KMT2A | |
| SCHEMBL7614840 | 0.89 | SLC2A1 (0.64) | SLC2A1IMPDH2MEN1KMT2AKDM4E | |
| SCHEMBL7614843 | 0.89 | SLC2A1 (0.64) | SLC2A1IMPDH2MEN1KMT2AKDM4E | |
| SCHEMBL7620256 | 0.88 | NAMPT (0.58) | NAMPTSLC2A1IMPDH2MEN1KMT2A | |
| SCHEMBL7618029 | 0.88 | NAMPT (0.58) | NAMPTIMPDH2MEN1KMT2AKDM4E | |
| SCHEMBL7620259 | 0.88 | NAMPT (0.58) | NAMPTSLC2A1IMPDH2MEN1KMT2A | |
| SCHEMBL7613190 | 0.86 | SLC2A1 (0.57) | NAMPTSLC2A1IMPDH2 | |
| SCHEMBL7613187 | 0.86 | SLC2A1 (0.57) | NAMPTSLC2A1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1100495-A4 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORP (US) | 2002-09-25 | — | — | EP | disclosed |
| EP-1100495-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-23 | — | — | EP | disclosed |
| WO-2000006153-A1 | PROPENAMIDES AS CCR5 MODULATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |