Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SHBG | P04278 | 3/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7618270 | 1.00 | AR (0.58) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL6401831 | 0.88 | AR (0.58) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL4268861 | 0.88 | AR (0.58) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL4268866 | 0.88 | AR (0.58) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL5071065 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL4263690 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL4263685 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL7616719 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL7616726 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 | |
| SCHEMBL4265769 | 0.86 | AR (0.57) | ARCYP19A1KMT2ASHBGNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880540-B1 | 17-BETA-CYCLOPROPYL(AMINO/OXY) 4-AZA STEROIDS AS ACTIVE INHIBITORS OF TESTOSTERONE 5-ALPHA-REDUCTASE AND C17-20-LYASE | AVENTIS PHARMA INC (US) | 2002-06-12 | — | — | EP | disclosed |
| US-6365597-B1 | FOR THERAPY OF ANDROGEN AND ESTROGEN MEDIATED DISORDERS, INCLUDING BENIGN PROSTATIC HYPERPLASIA, ANDROGEN MEDIATED PROSTATE CANCER, ESTROGEN MEDIATED BREAST CANCER AND ACNE | AVENTIS PHARMACEUTICALS INC. | 2002-04-02 | — | — | US | disclosed |