Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 16/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619017 | 1.00 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5358219 | 0.88 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5362332 | 0.83 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5362335 | 0.83 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL14575330 | 0.83 | PDE4B (0.54) | PDE4APDE4BPDE4CPDE4DPDE7A | |
| SCHEMBL5361396 | 0.82 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5361391 | 0.82 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14575579 | 0.82 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5755474 | 0.82 | PDE4B (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14575650 | 0.78 | PDE4B (0.65) | PDE4APDE4BPDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |