Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.57 |
| ▸ | CPT1A | P50416 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7619994 | 0.87 | PPARA (0.55) | PPARA | |
| SCHEMBL7613785 | 0.86 | PPARA (0.57) | PPARAMEN1KMT2ADRD2DRD4 | |
| SCHEMBL7617783 | 0.86 | PPARA (0.57) | PPARAMEN1KMT2ADRD2DRD4 | |
| SCHEMBL7614777 | 0.85 | MEN1 (0.50) | PPARAMEN1KMT2A | |
| SCHEMBL7613890 | 0.84 | SMN1; SMN2 (0.53) | PPARAHRH3MEN1KMT2A | |
| SCHEMBL28710418 | 0.79 | PPARA (0.84) | PPARAMEN1KMT2A | |
| SCHEMBL11012230 | 0.79 | PPARA (0.73) | PPARA | |
| SCHEMBL1115651 | 0.79 | PPARA (0.48) | PPARACPT1AHRH3MEN1KMT2A | |
| SCHEMBL6656919 | 0.78 | PPARA (0.60) | PPARACPT1AHRH3MEN1KMT2A | |
| SCHEMBL7615412 | 0.78 | HDAC3 (0.49) | PPARATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790824-B1 | 2,2-DICHLOROALKANE CARBOXYLIC ACIDS, PROCESS FOR PREPARING THE SAME, MEDICAMENT CONTAINING THE SAME, AND USE THEREOF FOR TREATING INSULIN RESISTANCE | ROCHE DIAGNOSTICS GMBH (DE) | 2002-02-06 | — | — | EP | disclosed |
| US-5968982-A | TREATMENT OF DIABETES | ROCHE DIAGNOSTICS GMBH (DE) | 1999-10-19 | — | — | US | disclosed |