Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620196 | 1.00 | PDPK1 (0.44) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7620191 | 1.00 | PDPK1 (0.44) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7617561 | 0.95 | CHRNA7 (0.45) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7617549 | 0.95 | CHRNA7 (0.45) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7626235 | 0.95 | CHRNA7 (0.45) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL7617553 | 0.95 | CHRNA7 (0.45) | PDPK1SLC18A3CHRNA7OPRM1OPRK1 | |
| SCHEMBL9748978 | 0.86 | PDPK1 (0.54) | PDPK1CHRNA7OPRM1OPRK1 | |
| SCHEMBL14367944 | 0.86 | PDPK1 (0.50) | PDPK1CHRNA7 | |
| SCHEMBL4863623 | 0.86 | PDPK1 (0.54) | PDPK1CHRNA7OPRM1OPRK1 | |
| SCHEMBL4863616 | 0.86 | PDPK1 (0.54) | PDPK1CHRNA7OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436954-B1 | BENZO(B)QUINOLIZIDINE AND BENZO(F)INDOLIZIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF ALZHEIMER'S DISEASE, SENILE DEMENTIA OR OTHER CONDITIONS CHARACTERIZED BY MEMORY LOSS; PYRROLO(1,2-B)ISOQUINOLINES, BENZO(B)QUINOLIZINES | AMERICAN BIOGENETIC SCIENCES, INC. | 2002-08-20 | — | — | US | disclosed |