Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 4/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.40 |
| ▸ | HPGDS | O60760 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18462787 | 0.97 | HCRTR1 (0.41) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL2710085 | 0.97 | HCRTR1 (0.41) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL206336 | 0.97 | HCRTR1 (0.41) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL17644214 | 0.92 | PRCP (0.46) | PRCPHCRTR1HCRTR2HPGDSNR1I2 | |
| SCHEMBL749228 | 0.92 | PRCP (0.44) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL206403 | 0.89 | PRCP (0.47) | PRCPHPGDSNR1I2ABCB11CYP3A4 | |
| SCHEMBL2707855 | 0.89 | PRCP (0.47) | PRCPHPGDSNR1I2ABCB11CYP3A4 | |
| SCHEMBL2709432 | 0.89 | HCRTR1 (0.44) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL205792 | 0.89 | HCRTR1 (0.44) | PRCPHCRTR1HCRTR2HPGDSCHEK2 | |
| SCHEMBL1294164 | 0.88 | PRCP (0.46) | PRCPHCRTR1HCRTR2HPGDSCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626716-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2020-03-25 | — | — | EP | disclosed |
| EP-3309157-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2018-04-18 | — | — | EP | disclosed |
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |
| CN-104016971-B | Antiviral compound | PHARMASSET INC. (US) | 2016-05-25 | — | — | CN | disclosed |
| EP-3002281-A1 | ANTIVIRAL COMPOUNDS | Gilead Pharmasset LLC (US) | 2016-04-06 | — | — | EP | disclosed |
| CN-103977406-A | Antiviral compounds | GILEAD SCIENCES INC | 2014-08-13 | — | — | CN | disclosed |
| EP-2430014-A1 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2012-03-21 | — | — | EP | disclosed |
| WO-2010132601-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2010-11-18 | — | — | WO | disclosed |