Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 17/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762066 | 1.00 | CETP (0.58) | CETPKCNH2KCNK3P2RX1LMNA | |
| SCHEMBL760518 | 0.89 | CETP (0.67) | CETPKCNH2KCNK3P2RX1LMNA | |
| SCHEMBL760517 | 0.89 | CETP (0.67) | CETPKCNH2KCNK3P2RX1LMNA | |
| SCHEMBL761285 | 0.85 | CETP (0.61) | CETPKCNH2KCNK3 | |
| SCHEMBL761286 | 0.85 | CETP (0.61) | CETPKCNH2KCNK3 | |
| SCHEMBL758559 | 0.85 | CETP (0.66) | CETPKCNH2 | |
| SCHEMBL761400 | 0.82 | CETP (0.66) | CETPKCNH2 | |
| SCHEMBL759800 | 0.81 | CETP (0.57) | CETPKCNH2 | |
| SCHEMBL761066 | 0.81 | CETP (0.57) | CETPKCNH2 | |
| SCHEMBL3068364 | 0.81 | CETP (0.69) | CETPKCNH2KCNK3P2RX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | claimed |
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | claimed |