Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.33 |
| ▸ | GBA1 | P04062 | 3/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466368 | 0.77 | IDO1 (0.41) | IDO1TDO2GBA1OPRK1 | |
| SCHEMBL5973963 | 0.74 | TDP1 (0.42) | IDO1TDO2SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL10778612 | 0.74 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3TAAR1 | |
| SCHEMBL7620984 | 0.72 | TAAR1 (0.37) | SLC6A4SLC6A2SLC6A3TAAR1 | |
| SCHEMBL28496558 | 0.67 | CNR2 (0.48) | IDO1TDO2SLC6A4SLC6A2TAAR1 | |
| SCHEMBL27666865 | 0.67 | TAAR1 (0.46) | IDO1SLC6A4SLC6A2SLC6A3TAAR1 | |
| SCHEMBL1641620 | 0.66 | SLC6A2 (0.48) | SLC6A4SLC6A2SLC6A3TAAR1TSHR | |
| SCHEMBL19143212 | 0.66 | CYP19A1 (0.39) | SLC6A4SLC6A3 | |
| SCHEMBL19317398 | 0.66 | CYP19A1 (0.39) | SLC6A4SLC6A3 | |
| SCHEMBL25097170 | 0.64 | HRH1 (0.40) | IDO1TDO2SLC6A4GBA1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0906288-B1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2002-11-06 | — | — | EP | disclosed |
| US-6465505-B1 | SUCH AS 4-(2,6-DIMETHYLBENZYLAMINO OR BENZYLOXY)-2-METHYL BENZIMIDAZOLE; INHIBITING EXOGENOUS OR ENDOGENOUS STIMULATED GASTRIC ACID SECRETION; PREVENTION AND TREATMENT OF GASTRO-INTESTINAL INFLAMMATORY DISEASES | ASTRAZENECA AB (SE) | 2002-10-15 | — | — | US | disclosed |
| EP-0906288-A1 | NEW COMPOUNDS | Astra Aktiebolag (SE) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997047603-A1 | NEW COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1997-12-18 | — | — | WO | disclosed |