SCHEMBL7621635

SCHEMBL7621635

CCCC(c1ccc(O)cc1)c1c(O)cccc1P(=O)(O)O

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.37
ESR2 Q92731 1/20 0.37
GRM8 O00222 1/20 0.34
GRM4 Q14833 1/20 0.34
CYP1A2 P05177 2/20 0.33
CYP3A4 P08684 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
LMNA P02545 2/20 0.33
PGR P06401 1/20 0.33
CHRM2 P08172 1/20 0.33
ADORA3 P0DMS8 1/20 0.33
AR P10275 1/20 0.33
CYP2D6 P10635 1/20 0.33
MAPT P10636 1/20 0.33
CHRM1 P11229 1/20 0.33
ALOX15 P16050 1/20 0.33
DRD1 P21728 1/20 0.33
TBXA2R P21731 1/20 0.33
PTGS1 P23219 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7622320 0.89 ESR1 (0.39) ESR1ESR2GRM8GRM4CYP1A2
SCHEMBL7616348 0.87 HIF1A (0.36) LMNADRD1ADRA1AOPRM1DRD3
SCHEMBL7622726 0.84 ESR1 (0.37) ESR1ESR2GRM8GRM4CYP1A2
SCHEMBL7619530 0.81 INPPL1 (0.39) ESR1ESR2GRM8GRM4MAPT
SCHEMBL7622352 0.79 ESR1 (0.46) ESR1ESR2CYP1A2CYP3A4CYP2C9
SCHEMBL6396127 0.77 ESR1 (0.46) ESR1ESR2GRM8GRM4CYP1A2
SCHEMBL7621261 0.75 HIF1A (0.35) LMNADRD1ADRA1AOPRM1DRD3
SCHEMBL6396849 0.75 ESR1 (0.34) ESR1ESR2GRM8GRM4CYP3A4
SCHEMBL6403291 0.75 ESR1 (0.36) ESR1ESR2GRM8GRM4CYP2C9
SCHEMBL16528760 0.74 AOC3 (0.43) LMNANQO1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1175425-A2 INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2002-01-30 EP disclosed
WO-2000043402-A2 INHIBITORS OF INTESTINAL APICAL MEMBRANE NA/PHOSPHATE CO-TRANSPORTATION BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2000-07-27 WO disclosed