Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.42 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4538043 | 0.82 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL5356507 | 0.80 | PDE4B (0.65) | PDE4BSGPL1S1PR1PDE4APDE4C | |
| SCHEMBL5356498 | 0.80 | PDE4B (0.65) | PDE4BSGPL1S1PR1PDE4APDE4C | |
| SCHEMBL4517491 | 0.79 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4533075 | 0.77 | PDE4B (0.42) | PDE4B | |
| SCHEMBL4533418 | 0.77 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL7617153 | 0.76 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DL3MBTL1 | |
| SCHEMBL4532406 | 0.76 | PDE4B (0.38) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4535539 | 0.74 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7616352 | 0.73 | EHMT2 (0.42) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |