Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.58 |
| ▸ | AKT1 | P31749 | 3/20 | 0.58 |
| ▸ | MTOR | P42345 | 4/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.43 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.43 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.43 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.43 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732174 | 0.88 | PIK3CA (0.72) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL740192 | 0.84 | PIK3CA (0.58) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL730319 | 0.80 | PIK3CA (0.72) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729989 | 0.78 | PIK3CA (0.68) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729558 | 0.77 | PIK3CA (0.71) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729900 | 0.77 | PIK3CA (0.71) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729822 | 0.76 | PIK3CA (0.77) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL731322 | 0.76 | PIK3CA (0.66) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729583 | 0.75 | PIK3CA (0.65) | PIK3CAAKT1MTORPIK3CDPIK3CB | |
| SCHEMBL729300 | 0.75 | PIK3CA (0.67) | PIK3CAAKT1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165321-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2012-06-28 | — | — | US | disclosed |
| US-8138347-B2 | Quinoline derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-20100168100-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2010-07-01 | — | — | US | disclosed |
| US-20080300239-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168100-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | JAK3, PI4KA, PIP4K2A | PIK3CA 13/4885AKT1 95/4885MTOR 154/4885 |
| US-20120165321-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885AKT1 66/4885MTOR 59/4885 |
| US-20080300239-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PIK3CG, PIK3CB | PIK3CA 6/4885AKT1 66/4885MTOR 59/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.