Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR1 | P25024 | 5/20 | 0.50 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.50 |
| ▸ | ALB | P02768 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | RARB | P10826 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2338545 | 0.80 | CHRM1 (0.65) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL13433689 | 0.80 | CXCR1 (0.56) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2341090 | 0.80 | CXCR1 (0.56) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2338550 | 0.80 | CHRM1 (0.65) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2334888 | 0.80 | CHRM1 (0.65) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2336381 | 0.80 | CXCR1 (0.56) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL13433700 | 0.79 | PTGS1 (0.51) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2341496 | 0.79 | PTGS1 (0.51) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2364054 | 0.79 | CHRM1 (0.48) | CXCR1CXCR2PTGS1PTGS2LMNA | |
| SCHEMBL2341495 | 0.79 | PTGS1 (0.51) | CXCR1CXCR2PTGS1PTGS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444434-B1 | COMPOUNDS INHIBITING THE ACTIVATION OF FX TO FXA BY TF/FVIIA. THE COMPOUNDS ARE ANTICOAGULANTS. THE INVENTION ALSO RELATES TO A METHOD OF IDENTIFYING A DRUG CANDIDATE. | NOVO NORDISK A/S (DK) | 2002-09-03 | — | — | US | disclosed |
| US-6238878-B1 | DRUG SCREENING OF FACTOR VIII-TISSUE FACTOR INHIBITORS BY TESTING EFFECT ON FACTOR X ACTIVATION, FACTOR XA AMIDOLYTIC ASSAY, AND TISSUE FACTOR/FACTOR VIIA AMIDOLYTIC ASSAY; THEN SELECTING COMPOUND BASED ON RESULTS | NOVO NORKISK AIS (DK) | 2001-05-29 | — | — | US | disclosed |