Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 6/20 | 0.39 |
| ▸ | TPH1 | P17752 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7621263 | 0.85 | S1PR3 (0.41) | PTPN1S1PR1S1PR3TPH1S1PR5 | |
| SCHEMBL7623928 | 0.81 | PTPN1 (0.57) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL7625402 | 0.76 | PTPN1 (0.50) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL7165738 | 0.75 | PTPN1 (0.62) | PTPN1 | |
| SCHEMBL7168584 | 0.74 | PTPN1 (0.47) | PTPN1 | |
| SCHEMBL5401110 | 0.74 | PTPN2 (0.35) | PTPN1 | |
| SCHEMBL7182466 | 0.73 | PTPN1 (0.57) | PTPN1S1PR1S1PR3S1PR4S1PR5 | |
| SCHEMBL7594345 | 0.72 | PTPN1 (0.44) | PTPN1S1PR1S1PR3 | |
| SCHEMBL7204587 | 0.72 | PTPN1 (0.35) | PTPN1 | |
| SCHEMBL5390873 | 0.71 | NPC1 (0.35) | S1PR1S1PR3S1PR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486142-B2 | A,A-DIFLUOROBENZYLPHOSPHONIC ACID DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2002-11-26 | — | — | US | disclosed |
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | MERCK FROSST CANADA LTD. (CA) | 2002-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058644-A1 | Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | PPM1B, PTPRO, PTPA | PTPN1 13/4885S1PR1 2885/4885S1PR3 4002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.