Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355898 | 0.81 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355892 | 0.81 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355884 | 0.79 | DRD4 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355891 | 0.79 | DRD4 (0.42) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4517491 | 0.76 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355062 | 0.75 | APP (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5355064 | 0.75 | APP (0.40) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5352574 | 0.75 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5352571 | 0.75 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7617153 | 0.75 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423710-B1 | Cyclic AMP-specific phosphodiesterase inhibitors | ICOS CORPORATION | 2002-07-23 | — | — | US | disclosed |