Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.58 |
| ▸ | PDE4A | P27815 | 9/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354647 | 1.00 | PDE4B (0.58) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5350320 | 0.96 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5755229 | 0.94 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5360475 | 0.94 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5360473 | 0.94 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5407368 | 0.94 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL7436899 | 0.93 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5359627 | 0.90 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL14575649 | 0.90 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL14576183 | 0.90 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001047905-A1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORPORATION (US) | 2001-07-05 | — | — | WO | disclosed |