Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478696 | 0.89 | GRM2 (0.48) | GRM2TSHRELANEALDH1A1USP8 | |
| SCHEMBL29293789 | 0.89 | TSHR (0.50) | GRM2TSHRELANEHPGDUSP8 | |
| SCHEMBL21899538 | 0.88 | TSHR (0.48) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL7271849 | 0.85 | TSHR (0.42) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL17268321 | 0.85 | GRM2 (0.45) | GRM2TSHRELANEKDM4EGAA | |
| SCHEMBL12326417 | 0.85 | PDE9A (0.49) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL9455020 | 0.85 | HPGD (0.50) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL1133478 | 0.85 | TSHR (0.50) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL29993589 | 0.85 | TSHR (0.50) | GRM2TSHRESR2ELANEGABRG2 | |
| SCHEMBL23625611 | 0.83 | GRM2 (0.52) | GRM2TSHRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102738-B1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | LEHMANN BERND DR (DE) | 2002-12-04 | — | — | EP | claimed |
| EP-1102738-A1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | Great Lakes Chemical Konstanz GmbH (DE) | 2001-05-30 | — | — | EP | claimed |
| WO-2000003964-A1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | GREAT LAKES CHEMICAL KONSTANZ GMBH (DE) | 2000-01-27 | — | — | WO | claimed |
| CN-102557987-A | Method for preparing sartan antihypertensive drug side-chain | YICHANG CHANGJIANG PHARMACEUTICAL CO LTD | 2012-07-11 | — | — | CN | disclosed |
| EP-1102738-B1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | LEHMANN BERND DR (DE) | 2002-12-04 | — | — | EP | disclosed |
| EP-0659179-B1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-1102738-A1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | Great Lakes Chemical Konstanz GmbH (DE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000003964-A1 | METHOD FOR THE ACIDIC OR ALKALINE SAPONIFICATION OF BIPHENYL NITRILES | GREAT LAKES CHEMICAL KONSTANZ GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| US-5968924-A | HAVE THE ABILITY TO STIMULATE THE RELEASE OF NATURAL OR ENDOGENOUS GROWTH HORMONE; TREATMENT OF OBESITY, OSTEOPOROSIS | MERCK & CO., INC. (US) | 1999-10-19 | — | — | US | disclosed |
| US-5672596-A | ANIMAL GROWTH CONTROLLERS | MERCK & CO., INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0513974-B1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO INC (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5310737-A | Benzo-fused lactams that promote the release of growth hormone | MERCK & CO., INC. (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1994005634-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5254546-A | Hypotensive agent | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-10-19 | — | — | US | disclosed |
| US-5206235-A | Animal growth regulators; stimulants | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0513974-A1 | Novel benzo-fused lactams that promote the release of growth hormone | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0479892-A1 | FUSED-RING ARYL SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-04-15 | — | — | EP | disclosed |
| WO-1991000277-A1 | SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | disclosed |
| WO-1991000281-A2 | FUSED-RING ARYL SUBSTITUTED IMIDAZOLES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-01-10 | — | — | WO | disclosed |