Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.73 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.73 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.73 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.73 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6640691 | 0.90 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6642849 | 0.88 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6640467 | 0.86 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6639813 | 0.86 | MAPK14 (0.75) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6642185 | 0.86 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6641436 | 0.85 | MAPK14 (0.68) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6638752 | 0.85 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6643419 | 0.85 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6639932 | 0.85 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11ADORA2A | |
| SCHEMBL6639110 | 0.84 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440973-B1 | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents | AMGEN INC. | 2002-08-27 | — | — | US | disclosed |