Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL763858 | 0.95 | KCNH2 (0.42) | HRH1KCNH2CYP2D6CHRM1KLK5 | |
| SCHEMBL763220 | 0.93 | TP53 (0.41) | HRH1KCNH2CYP2D6CHRM1MCHR1 | |
| SCHEMBL16301247 | 0.92 | KCNH2 (0.41) | HRH1KCNH2CYP2D6CHRM1MCHR1 | |
| SCHEMBL762785 | 0.91 | HRH1 (0.42) | HRH1KCNH2CYP2D6CHRM1CTSB | |
| SCHEMBL739548 | 0.91 | HRH1 (0.41) | HRH1KCNH2CYP2D6CHRM1KLK5 | |
| SCHEMBL739547 | 0.91 | HRH1 (0.41) | HRH1KCNH2CYP2D6CHRM1KLK5 | |
| SCHEMBL16301237 | 0.90 | HRH1 (0.40) | HRH1KCNH2CYP2D6CHRM1KLK5 | |
| SCHEMBL16301236 | 0.90 | KCNH2 (0.47) | HRH1KCNH2CYP2D6CHRM1MCHR1 | |
| SCHEMBL739119 | 0.90 | HRH1 (0.39) | HRH1KCNH2CYP2D6CHRM1HRH2 | |
| SCHEMBL739120 | 0.90 | HRH1 (0.39) | HRH1KCNH2CYP2D6CHRM1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |
| US-8138168-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-20 | — | — | US | disclosed |