Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762871 | 0.78 | NPC1 (0.52) | NPC1PKMPIM3PIM2L3MBTL1 | |
| SCHEMBL26983433 | 0.70 | CSNK2A2 (0.55) | NPC1PKMPIM3PIM2CSNK2A2 | |
| SCHEMBL742358 | 0.69 | KDM4E (0.43) | NPC1PKMPIM3PIM2L3MBTL1 | |
| SCHEMBL742663 | 0.69 | CSNK2A2 (0.40) | CSNK2A2CSNK2BCSNK2A1KDRALDH1A1 | |
| SCHEMBL17796531 | 0.67 | KDM4E (0.40) | NPC1PKMALDH1A1GRM6HSP90AB1 | |
| SCHEMBL14200571 | 0.65 | KDM4E (0.43) | NPC1L3MBTL1ALDH1A1KDM4EGLA | |
| SCHEMBL17900427 | 0.64 | GRM6 (0.43) | L3MBTL1ALDH1A1GRM6KDM4EHPGD | |
| SCHEMBL8549434 | 0.64 | TSHR (0.44) | L3MBTL1ALDH1A1GRM6HPGDHSD17B10 | |
| SCHEMBL8498605 | 0.64 | GRM6 (0.40) | ALDH1A1GRM6GAACISD2 | |
| SCHEMBL27805811 | 0.64 | GRM6 (0.40) | NPC1PKML3MBTL1ALDH1A1GRM6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138217-B2 | Aurora kinase inhibitors; proliferative disorders; anticancer agents; antitumor agents; N-(1-methyl-1-phenylethyl)-3-((4-morpholin-4-ylbenzoyl)amino)-1H-thieno(2,3-c)pyrazole-5-carboxamide | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-03-20 | — | — | US | disclosed |