Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29213552 | 0.88 | CYP3A4 (0.46) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| SCHEMBL29106838 | 0.87 | TSHR (0.54) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| SCHEMBL435538 | 0.87 | CYP3A4 (0.50) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| Butyric Acid SCHEMBL10589842 | 0.87 | HDAC3 (0.54) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| R-Chloropropionate SCHEMBL9049894 | 0.87 | CYP3A4 (0.50) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| Butyric Acid SCHEMBL10187724 | 0.85 | FFAR3 (0.52) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| Bicarbonate SCHEMBL27340734 | 0.84 | CYP3A4 (0.75) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| Bicarbonate SCHEMBL11213893 | 0.84 | CYP3A4 (0.75) | CYP3A4TDP1ESR1ESR2ALDH1A1 | |
| SCHEMBL11481515 | 0.83 | HDAC3 (0.47) | CYP3A4TDP1NR4A2ESR1ESR2 | |
| SCHEMBL10697631 | 0.83 | HDAC3 (0.47) | CYP3A4TDP1NR4A2ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780452-B1 | Aqueous paint | TOYO SEIKAN KAISHA LTD (JP) | 2002-03-06 | — | — | EP | disclosed |
| US-5763507-A | EPOXY ACRYLATE RESIN | TOYO SEIKAN KAISHA, LTD. (JP) | 1998-06-09 | — | — | US | disclosed |
| EP-0780452-A2 | Aqueous paint | TOYO SEIKAN KAISHA LIMITED (JP) | 1997-06-25 | — | — | EP | disclosed |
| CN-1016430-B | Process for preparing cationically improved epoxy resin compositions | DOW CHEMICAL CO (US) | 1992-04-29 | — | — | CN | disclosed |
| CN-1052320-A | Electrodeposition coating composition of the Resins, epoxy that the cation type has improved and uses thereof | DOW CHEMICAL CO (US) | 1991-06-19 | — | — | CN | disclosed |
| CN-87104910-A | Cationic improved epoxy resin compositions | — | 1988-05-04 | — | — | CN | disclosed |
| EP-0189474-A1 | A PROCESS FOR THE PREPARATION OF EPOXY RESINS OF CONTROLLED CONVERTION. | DOW CHEMICAL CO (US) | 1986-08-06 | — | — | EP | disclosed |
| WO-1986001216-A1 | EPOXY RESINS OF CONTROLLED CONVERSION AND A PROCESS FOR THEIR PREPARATION | THE DOW CHEMICAL COMPANY (US) | 1986-02-27 | — | — | WO | disclosed |