Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FADS1 | O60427 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | GAK | O14976 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12240919 | 0.85 | MAPKAPK2 (0.64) | EGFRERBB2MAPK14MAPK9KDR | |
| SCHEMBL7617911 | 0.84 | EGFR (0.71) | EGFRERBB2CA9FADS1GAK | |
| SCHEMBL24006270 | 0.84 | CCNC (0.59) | EGFRERBB2KDRCA9MAPK1 | |
| SCHEMBL7622000 | 0.83 | CA9 (0.46) | EGFRERBB2MAPK14MAPK9CA9 | |
| SCHEMBL7618832 | 0.83 | GAK (0.69) | EGFRERBB2MAPK14KDRMAPKAPK2 | |
| SCHEMBL30307396 | 0.83 | EGFR (0.69) | EGFRERBB2MAPK14KDRFADS1 | |
| Hydrochloric Acid SCHEMBL9073088 | 0.82 | GAK (0.68) | EGFRERBB2MAPK14KDRMAPKAPK2 | |
| SCHEMBL12218168 | 0.82 | MAPKAPK2 (0.60) | MAPK14MAPK9KDRMAPK1MAPKAPK2 | |
| SCHEMBL28199613 | 0.82 | CA9 (0.47) | EGFRERBB2MAPK14CA9FADS1 | |
| SCHEMBL7620779 | 0.81 | ABCG2 (0.52) | EGFRERBB2MAPK14CA9FADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1263503-A2 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | AMERICAN CYANAMID COMPANY (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2001068186-A2 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | AMERICAN CYANAMID COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |
| EP-0973746-A1 | SUBSTITUTED 3-CYANO QUINOLINES | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998043960-A1 | SUBSTITUTED 3-CYANO QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1998-10-08 | — | — | WO | disclosed |