Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.43 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3292827 | 1.00 | KDM1A (0.51) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL3292821 | 1.00 | KDM1A (0.51) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL12084783 | 1.00 | KDM1A (0.51) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| Hydrochloric Acid SCHEMBL7629295 | 0.99 | KDM1A (0.50) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL241680 | 0.91 | KDM1A (0.48) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL241681 | 0.91 | KDM1A (0.48) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL6394296 | 0.87 | KDM1A (0.46) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL3752156 | 0.87 | KDM1A (0.46) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL31096660 | 0.87 | KDM1A (0.46) | KDM1AHDAC1HDAC8HDAC6GPR119 | |
| SCHEMBL31693865 | 0.86 | KDM1A (0.46) | KDM1AHDAC1GPR119USP30NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410548-B2 | THERAPY FOR OBESITY, DIABETES, SEXUAL DISORDERS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |
| US-20010029259-A1 | Spiropiperidine derivatives as melanocortin receptor agonists | MERCK SHARP & DOHME CORP. | 2001-10-11 | — | — | US | disclosed |
| EP-1085869-A4 | SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO INC (US) | 2001-10-04 | — | — | EP | disclosed |
| US-6294534-B1 | TREATMENT OF DISORDERS RESPONSIVE TO THE ACTIVATION OF MELANOCORTIN RECEPTORS, SUCH AS OBESITY, DIABETES OR MALE OR FEMALE SEXUAL DYSFUNCTION. | MERCK & CO., INC. | 2001-09-25 | — | — | US | disclosed |
| EP-1085869-A1 | SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064002-A1 | SPIROPIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 1999-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010029259-A1 | Spiropiperidine derivatives as melanocortin receptor agonists | MC5R, MC4R, MC3R | KDM1A 3336/4885HDAC1 1899/4885HDAC8 2687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.