SCHEMBL7633728

SCHEMBL7633728

COC(=O)[C@@H](N)Cc1ccc(O)cc1Cl

nearest known ligand 0.48

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 12/20 0.48
HDAC3 O15379 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
ESR1 P03372 3/20 0.40
GAA P10253 1/20 0.40
ESR2 Q92731 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
KMT2A Q03164 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30036796 1.00 HDAC8 (0.48) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL23387519 1.00 HDAC8 (0.48) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL15105038 1.00 HDAC8 (0.48) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL2895605 0.87 HDAC8 (0.56) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL3751401 0.87 HDAC8 (0.56) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL2895608 0.87 HDAC8 (0.56) HDAC8HDAC3HDAC1HDAC2HDAC6
Hydrochloric Acid SCHEMBL3740714 0.85 HDAC8 (0.58) HDAC8HDAC3HDAC1HDAC2HDAC6
Hydrochloric Acid SCHEMBL3751396 0.85 HDAC8 (0.58) HDAC8HDAC3HDAC1HDAC2HDAC6
Hydrochloric Acid SCHEMBL3740720 0.85 HDAC8 (0.58) HDAC8HDAC3HDAC1HDAC2HDAC6
SCHEMBL2491363 0.85 HDAC8 (0.43) HDAC8HDAC3HDAC1HDAC2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6369098-B1 PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-.GAMMA. (PPAR.GAMMA.) AND/OR PPAR.ALPHA TREATMENT OF ENDOCRINE, SKIN, CARDIOVASCULAR, IMMUNOLOGICAL, NEUROLOGICAL, NEUROPSYCHIATRIC, NEOPLASTIC AND CHRONIC VIRAL DISEASES OF VARIOUS ORGANS BETHESDA PHARMACEUTICALS, INC. 2002-04-09 US disclosed
WO-2001025226-A1 DITHIOLANE DERIVATIVES BETHESDA PHARMACEUTICALS, INC. (US) 2001-04-12 WO disclosed