Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967419 | 0.84 | KDM4E (0.41) | POLBAPEX1TDP1KDM4ELMNA | |
| SCHEMBL4967632 | 0.84 | KDM4E (0.41) | POLBAPEX1TDP1KDM4ELMNA | |
| SCHEMBL472764 | 0.84 | KDM4E (0.41) | POLBAPEX1TDP1KDM4ELMNA | |
| SCHEMBL23986615 | 0.79 | CHRM1 (0.41) | POLBAPEX1TDP1KDM4ELMNA | |
| SCHEMBL30358612 | 0.79 | POLB (0.31) | POLBAPEX1TDP1 | |
| SCHEMBL7874382 | 0.78 | — | — | |
| SCHEMBL7715385 | 0.76 | POLB (0.30) | POLBAPEX1TDP1 | |
| SCHEMBL301572 | 0.71 | KDM4E (0.40) | TDP1KDM4ELMNA | |
| SCHEMBL13791007 | 0.71 | KDM4E (0.40) | TDP1KDM4ELMNA | |
| SCHEMBL1299179 | 0.71 | KDM4E (0.40) | TDP1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790974-B1 | SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS | BAYER AG (US) | 2002-08-14 | — | — | EP | claimed |