Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Enrasentan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA known ✓ | P25101 | 20/20 | 1.00 |
| ▸ | EDNRB known ✓ | P24530 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Enrasentan SCHEMBL29356829 | 1.00 | EDNRA (1.00) | EDNRAEDNRB | |
| Enrasentan SCHEMBL8206689 | 1.00 | EDNRA (1.00) | EDNRAEDNRB | |
| Enrasentan SCHEMBL1031130 | 1.00 | EDNRA (1.00) | EDNRAEDNRB | |
| Enrasentan SCHEMBL1649828 | 1.00 | EDNRA (1.00) | EDNRAEDNRB | |
| Enrasentan SCHEMBL8008492 | 0.98 | EDNRA (0.97) | EDNRAEDNRB | |
| Enrasentan SCHEMBL7660593 | 0.98 | EDNRA (0.95) | EDNRAEDNRB | |
| Enrasentan SCHEMBL7610103 | 0.98 | EDNRA (0.95) | EDNRAEDNRB | |
| SCHEMBL13038489 | 0.97 | EDNRA (0.93) | EDNRAEDNRB | |
| SCHEMBL8203979 | 0.97 | EDNRA (0.93) | EDNRAEDNRB | |
| SCHEMBL7538909 | 0.96 | EDNRA (0.92) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410554-B1 | ADRENERGIC ANTAGONIST | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |